Hodgkin's disease: biology, treatment, prognosis

Hodgkins lymphoma: treatment and prognosis

Supported in part by a grant provided by “IASIS” a non-profit organization raising funds for Research in Leukemias, Lymphomas and related disorders come. AAS I/IIA are definitely non-advanced for most study groups. Non-advanced stages are further classified as “early” or “early favourable” and “intermediate” or “early unfavourable” according to the presence of adverse features. Table 1 summariz...

Hodgkin's disease: biology, treatment, prognosis.

Current strategies in the treatment of childhood Hodgkins disease.

Dramatic changes in the treatment of childhood Hodgkins disease have taken place during the past three decades. Contemporary combined modality treatment regimens produce durable disease-free survival in 90 to 100%of patients with early disease and in 70 to 85%of patients with advanced disease. Studies using chemotherapy alone also report high survival rates, and current studies are few to highl...

Medulloblastoma: Tumor Biology and Relevance to Treatment and Prognosis Paradigm.

Medulloblastoma is a malignant embryonic brain tumor arising in the posterior fossa and typically occurring in pediatric patients. Current multimodal treatment regimes have significantly improved the survival rates; however, a marked heterogeneity in therapy response is observed, and one third of all patients die within 5 years after diagnosis. Large-scale genetic and transcriptome analysis rev...

Biology and Treatment of Hemophagocytic Lymphohistiocytosis

Hemophagocytic lymphohistocytosis (HLH) is a hyperinflammatory syndrome that occurs at all ages and is characterized by high levels of cytokines, secreted by activated T-lymphocytes and macrophages. All symptoms and laboratory changes can be explained by organ infiltration by these cells and hypercytokinemia. HLH occurs as an inherited form (genetic, primary HLH) with mutations primarily in the...